WEB-based GEne SeT AnaLysis Toolkit
 
Translating gene lists into biological insights...
 


User data and parameters: User data: textAreaUpload.txt, Organism: hsapiens, Id Type: ensembl_gene_stable_id, Ref Set: entrezgene, Significance Level: Top10, Statistics Test: Hypergeometric, MTC: BH, Minimum: 2

The results for each enriched gene sets are listed in this table.
For each gene set, the first row lists database name, gene set name , and corresponding gene set ID.
The second row lists the following statistics:
Finally, genes in the pathway are listed. For each gene, the table lists the user uploaded ID and value (optional), Entrez ID, Ensembl Gene Stable ID, Gene symbol, and description. Ensembl Gene Stable ID and Entrez Gene ID are linked to the Ensembl and Entrez Gene databases, respectively.

Database:KEGG pathway       Name:RNA transport       ID:03013
C=151; O=5; E=0.41; R=12.31; rawP=5.78e-05; adjP=0.0008
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000100813 NA ACIN1 apoptotic chromatin condensation inducer 1 22985 ENSG00000100813
2  ENSG00000125450 NA NUP85 nucleoporin 85kDa 79902 ENSG00000125450
3  ENSG00000196313 NA POM121 POM121 transmembrane nucleoporin 9883 ENSG00000196313
4  ENSG00000108349 NA CASC3 cancer susceptibility candidate 3 22794 ENSG00000108349
5  ENSG00000135213 NA POM121C POM121 transmembrane nucleoporin C 100101267 ENSG00000135213


Database:KEGG pathway       Name:Lysine degradation       ID:00310
C=44; O=3; E=0.12; R=25.35; rawP=0.0002; adjP=0.0013
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000139718 NA SETD1B SET domain containing 1B 23067 ENSG00000139718
2  ENSG00000099381 NA SETD1A SET domain containing 1A 9739 ENSG00000099381
3  ENSG00000181090 NA EHMT1 euchromatic histone-lysine N-methyltransferase 1 79813 ENSG00000181090


Database:KEGG pathway       Name:Hedgehog signaling pathway       ID:04340
C=56; O=2; E=0.15; R=13.28; rawP=0.0100; adjP=0.0433
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000163482 NA STK36 serine/threonine kinase 36 27148 ENSG00000163482
2  ENSG00000213923 NA CSNK1E casein kinase 1, epsilon 1454 ENSG00000213923


Database:KEGG pathway       Name:Phosphatidylinositol signaling system       ID:04070
C=78; O=2; E=0.21; R=9.53; rawP=0.0189; adjP=0.0459
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000148384 NA INPP5E inositol polyphosphate-5-phosphatase, 72 kDa 56623 ENSG00000148384
2  ENSG00000145214 NA DGKQ diacylglycerol kinase, theta 110kDa 1609 ENSG00000145214


Database:KEGG pathway       Name:mRNA surveillance pathway       ID:03015
C=83; O=2; E=0.22; R=8.96; rawP=0.0212; adjP=0.0459
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000100813 NA ACIN1 apoptotic chromatin condensation inducer 1 22985 ENSG00000100813
2  ENSG00000108349 NA CASC3 cancer susceptibility candidate 3 22794 ENSG00000108349


Database:KEGG pathway       Name:Glycerophospholipid metabolism       ID:00564
C=80; O=2; E=0.22; R=9.29; rawP=0.0198; adjP=0.0459
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000087157 NA PGS1 phosphatidylglycerophosphate synthase 1 9489 ENSG00000087157
2  ENSG00000145214 NA DGKQ diacylglycerol kinase, theta 110kDa 1609 ENSG00000145214


Database:KEGG pathway       Name:Pyrimidine metabolism       ID:00240
C=99; O=2; E=0.27; R=7.51; rawP=0.0294; adjP=0.0541
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000177084 NA POLE polymerase (DNA directed), epsilon, catalytic subunit 5426 ENSG00000177084
2  ENSG00000181222 NA POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 5430 ENSG00000181222


Database:KEGG pathway       Name:Metabolic pathways       ID:01100
C=1130; O=7; E=3.04; R=2.30; rawP=0.0333; adjP=0.0541
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000148384 NA INPP5E inositol polyphosphate-5-phosphatase, 72 kDa 56623 ENSG00000148384
2  ENSG00000136699 NA SMPD4 sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3) 55627 ENSG00000136699
3  ENSG00000177084 NA POLE polymerase (DNA directed), epsilon, catalytic subunit 5426 ENSG00000177084
4  ENSG00000087157 NA PGS1 phosphatidylglycerophosphate synthase 1 9489 ENSG00000087157
5  ENSG00000181222 NA POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 5430 ENSG00000181222
6  ENSG00000145214 NA DGKQ diacylglycerol kinase, theta 110kDa 1609 ENSG00000145214
7  ENSG00000115275 NA MOGS mannosyl-oligosaccharide glucosidase 7841 ENSG00000115275


Database:KEGG pathway       Name:Lysosome       ID:04142
C=121; O=2; E=0.33; R=6.15; rawP=0.0423; adjP=0.0601
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000125447 NA GGA3 golgi-associated, gamma adaptin ear containing, ARF binding protein 3 23163 ENSG00000125447
2  ENSG00000100083 NA GGA1 golgi-associated, gamma adaptin ear containing, ARF binding protein 1 26088 ENSG00000100083


Database:KEGG pathway       Name:Spliceosome       ID:03040
C=127; O=2; E=0.34; R=5.85; rawP=0.0462; adjP=0.0601
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000063244 NA U2AF2 U2 small nuclear RNA auxiliary factor 2 11338 ENSG00000063244
2  ENSG00000100813 NA ACIN1 apoptotic chromatin condensation inducer 1 22985 ENSG00000100813




WebGestalt is currently developed and maintained by Jing Wang and Bing Zhang at the Zhang Lab. Other people who have made significant contribution to the project include Dexter Duncan, Stefan Kirov, Zhiao Shi, and Jay Snoddy.

Funding credits: NIH/NIAAA (U01 AA016662, U01 AA013512); NIH/NIDA (P01 DA015027); NIH/NIMH (P50 MH078028, P50 MH096972); NIH/NCI (U24 CA159988); NIH/NIGMS (R01 GM088822).